If you are looking for a top-level motherboard, it is not easy to choose these days. After you decide which brand of CPU to use, you need to determine whether you want to SLI two Video cards or not. These choices will eliminate a lot of brands and models. Which choice of CPU to use is hard, but most of the enthusiasts out there already have their favorites. From what I have seen on my tests, AMD has a slight edge on games and Intel has a slight edge on Office and media applications. But fans of either CPU's will not notice the difference. So after you choose your team, the choice of chipset follows.
If you want to the SLI route, there is a single choice; the nForce 4 SLI Chipset. I heard that nVidia and Intel are still negotiating to implement SLI on the 955 chipset; But the 955 chipset doesn't support SLI yet. It is too bad though, because I noticed that the 955 motherboards have an edge on memory intensive applications among all motherboards. I think I don't need to introduce top tier motherboard manufacturers anymore, especially ASUS. After the ASUSP4C800-E Deluxe, I have not found other models or chipset releases to call a "flagship" motherboard. But with the transition to LGA775, dual core CPU's requires the new chipsets for users. Let's see if P5WD2 Premium is worthy to be the next flagship of ASUS.