"Default" BIOS settings assure that you should have a working setup. For the best performance, you have to go through each page of the BIOS to ensure that the controls and physical elements are compatible. Normally, a BIOS program will have extra features that do not relate to all setups.. and should be disabled. This is true when a video card is used instead of on-board video, or a sound card instead of the on-board audio. Ensure that any associated features for a device are similarly disabled, if an add-in card is used, or the feature is not in use itself. A modem setting would be useless, unless the device is active. Same with MIDI or game ports. Thermal limits for the CPU health should also be set per the physical relation of the system. Same with some system fans.. if not in place, then an "ignore" setting should be used. Only if on-board video is used, then a video aperture is required. Not so with an add-in video card! Set dedicated video to no more than 20% of total system memory. With a video card, set the aperture to minimum. For memory settings, use the
SPD factor for best results. Setting latency timing beyond what is recommended may cause the paging to miss a step, or "tick" on the timing rhythm.. and you have paging errors or a BSOD.
Note the first screens before the bootstrap process.. if latency is off, an error message should be displayed. But likely not, if a 'package' system!
CPU-Z would give an ID of the memory modules, from the "SPD" tab. Compare that ID tag to what is recommended by the motherboard vendor QVL listing to ensure they are compatible. After a motherboard model is released, newer memory types may be compatible. The "Memory Advisor" at
www.crucial.com/ will suggest the best choices for a system. Enter the key factors for a proper match of memory to system. You don't have to purchase memory from them, but the results can guide you to proper memory modules.
F@H.. to solve mankind's maladies.. in our lifetimes!