Good to have you back in the "fold".
Best would be the Console version on the desktop, set your prefs and "let 'er rip" so to speak. If you have a multi-core CPU, it can do two WUs simultaneously, as long as they have different folder names (or on different drives). The laptop would be best with only one WU at a time. Of course, it would have to always be on AC power, and may need a cooling plate or other means to keep it at a happy temperature. Should run normally with the lid closed. Guess you know the link for the Console version commands..
I use a Console control for each WU, launched from a desktop link.. not as a service-related start.
I would do a 24/7 folding routine, but electric costs by me are at $0.175 per KWH! Hope they are less in your area.
F@H.. to solve mankind's maladies.. in our lifetimes!